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Pflugers Arch. 2012 Apr;463(4):585-92. doi: 10.1007/s00424-012-1077-z. Epub 2012 Feb 7.

Pannexin 1 forms an anion-selective channel.

Author information

1
Faculty of Life Sciences, The University of Manchester, Smith Building, Oxford Road, Manchester, UK.

Abstract

Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)> I(-) > Br (-)> Cl (-) > F (-)>> aspartate (-)≈ glutamate (-)≈ gluconate(-). Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance.

PMID:
22311122
DOI:
10.1007/s00424-012-1077-z
[Indexed for MEDLINE]

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