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Maturitas. 2012 Apr;71(4):385-8. doi: 10.1016/j.maturitas.2012.01.006. Epub 2012 Feb 10.

Testosterone pellet implants and migraine headaches: a pilot study.

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Millennium Wellness Center, 228 E. Spring Valley Road, Dayton, OH 45458, USA.


The purpose of this prospective pilot study was to determine the therapeutic effect of continuous testosterone, delivered as a subcutaneous implant, on the severity of migraine headaches in pre- and post-menopausal patients. Twenty-seven women with a history of documented migraine headache were asked to rate their headache severity using a five-point scale at baseline (prior to therapy); and again, 3 months following treatment with testosterone implants. Improvement in headache severity was noted by 92% of patients and the mean level of improvement was statistically significant (3.3 on a 5 point scale). In addition, there was no difference in the level of improvement between pre- and post-menopausal cohorts. Seventy-four percent of patients reported a headache severity score of '0' (none) on testosterone implant therapy for the 3-month treatment period. Continuous testosterone was effective therapy in reducing the severity of migraine headaches in both pre- and post-menopausal women.

[Indexed for MEDLINE]

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