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Exp Cell Res. 2012 Jul 1;318(11):1324-31. doi: 10.1016/j.yexcr.2012.01.019. Epub 2012 Jan 28.

Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions.

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Division of Immunogenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.


c-FLIP proteins (isoforms: c-FLIP(L), c-FLIP(S), and c-FLIP(R)) play an essential role in the regulation of death receptor (DR)-induced apoptosis and NF-κB activation. Here, we discuss multiple mechanisms by which c-FLIPs control NF-κB activation and the life/death decision made in cancer and immune cells. We focus on the role of c-FLIP in cellular signaling. We concentrate on c-FLIP protein modifications as well as on the regulation of c-FLIP expression levels. Furthermore, we discuss in detail how the exact quantity and dynamics of different c-FLIP isoforms in the cell influence the induction of pro- versus anti-apoptotic pathways.

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