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Angew Chem Int Ed Engl. 2012 Mar 12;51(11):2643-6. doi: 10.1002/anie.201107695. Epub 2012 Feb 3.

Tetrahydroxynaphthalene reductase: catalytic properties of an enzyme involved in reductive asymmetric naphthol dearomatization.

Author information

1
Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Germany.

Abstract

In reduced circumstances: tetrahydroxynaphthalene reductase shows a broad substrate range including alternate phenolic compounds and cyclic ketones. Structural modeling reveals major enzyme-substrate interactions; C-terminal truncation of the enzyme causes an altered substrate preference, in accordance with stabilization of the substrate by the C-terminal carboxylate. This effect allows the identification of a homologous enzyme.

PMID:
22308069
DOI:
10.1002/anie.201107695
[Indexed for MEDLINE]

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