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Nat Genet. 2012 Feb 5;44(3):257-9. doi: 10.1038/ng.1080.

Common variants at 11p13 are associated with susceptibility to tuberculosis.

Author information

1
Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Abstract

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

PMID:
22306650
PMCID:
PMC3427019
DOI:
10.1038/ng.1080
[Indexed for MEDLINE]
Free PMC Article

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