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Cell Stem Cell. 2012 Feb 3;10(2):115-9. doi: 10.1016/j.stem.2012.01.001.

The potential of stem cells as an in vitro source of red blood cells for transfusion.

Author information

1
Tisch Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA. annarita.migliaccio@mssm.edu

Abstract

Recent advances have increased excitement about the potential for therapeutic production of red blood cells (RBCs) in vitro. However, generation of RBCs in the large numbers required for transfusion remains a significant challenge. In this article, we summarize recent progress in producing RBCs from various cell sources, and discuss the hurdles that remain for translation into the clinical arena.

PMID:
22305561
PMCID:
PMC3676433
DOI:
10.1016/j.stem.2012.01.001
[Indexed for MEDLINE]
Free PMC Article

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