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Emerg Infect Dis. 2012 Feb;18(2):248-55. doi: 10.3201/eid1802.111492.

Characterization of Nipah virus from outbreaks in Bangladesh, 2008-2010.

Author information

1
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. mko2@cdc.gov

Abstract

Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.

PMID:
22304936
PMCID:
PMC3310473
DOI:
10.3201/eid1802.111492
[Indexed for MEDLINE]
Free PMC Article

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