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Cell. 2012 Feb 3;148(3):583-95. doi: 10.1016/j.cell.2011.12.022.

Visualizing neuromodulation in vivo: TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing.

Author information

1
Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.

Erratum in

  • Cell. 2012 Mar 2;148(5):1065.

Abstract

Behavior cannot be predicted from a "connectome" because the brain contains a chemical "map" of neuromodulation superimposed upon its synaptic connectivity map. Neuromodulation changes how neural circuits process information in different states, such as hunger or arousal. Here we describe a genetically based method to map, in an unbiased and brain-wide manner, sites of neuromodulation under different conditions in the Drosophila brain. This method, and genetic perturbations, reveal that the well-known effect of hunger to enhance behavioral sensitivity to sugar is mediated, at least in part, by the release of dopamine onto primary gustatory sensory neurons, which enhances sugar-evoked calcium influx. These data reinforce the concept that sensory neurons constitute an important locus for state-dependent gain control of behavior and introduce a methodology that can be extended to other neuromodulators and model organisms.

PMID:
22304923
PMCID:
PMC3295637
DOI:
10.1016/j.cell.2011.12.022
[Indexed for MEDLINE]
Free PMC Article

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