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J Nat Prod. 2012 Feb 24;75(2):257-61. doi: 10.1021/np2004165. Epub 2012 Feb 3.

Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.

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1
Laboratoire de Pharmacognosie Associé au CNRS UMR 8076 BioCIS, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud, 5 Rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France.

Abstract

Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.

PMID:
22304006
DOI:
10.1021/np2004165
[Indexed for MEDLINE]
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