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J Am Chem Soc. 2012 Feb 29;134(8):3631-4. doi: 10.1021/ja210719s. Epub 2012 Feb 13.

Boronate-mediated biologic delivery.

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1
Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Abstract

Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells.

PMID:
22303837
PMCID:
PMC3304437
DOI:
10.1021/ja210719s
[Indexed for MEDLINE]
Free PMC Article
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