Format

Send to

Choose Destination
Head Neck. 2013 Jun;35(6):E175-7. doi: 10.1002/hed.22918. Epub 2012 Feb 2.

Hyperparathyroidism-jaw tumor syndrome.

Author information

1
Faculty of Medicine, Dalhousie University, Dalhousie University, Halifax, Nova Scotia, Canada.

Abstract

BACKGROUND:

Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a rare autosomal dominant multiple tumor syndrome characterized by hyperparathyroidism due to single or multiple-gland parathyroid tumor(s). Since it was first described in 1990, the genetics underlying the syndrome have been elucidated and typical clinical presentations are becoming clarified as literature describing this rare entity amasses.

METHODS AND RESULTS:

A 22-year-old man presented with a 2-year history of fatigue, weight loss, nausea, and vomiting. Anemia workup indicated severe hypercalcemia. Investigations were consistent with a diagnosis of HPT-JT. The patient underwent a total 4-gland parathyroidectomy with single gland reimplantation.

CONCLUSION:

HPT-JT is a complex syndrome with phenotypic manifestations that can seem physiologically and temporally unrelated. The risk of parathyroid carcinoma is elevated in patients with HPT-JT, necessitating rapid treatment and complete tumor resection to reduce the morbidity and mortality associated with intractable hypercalcemia due to local recurrence or metastatic disease.

PMID:
22302605
DOI:
10.1002/hed.22918
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center