Send to

Choose Destination
See comment in PubMed Commons below
Am J Clin Nutr. 2012 Mar;95(3):656-69. doi: 10.3945/ajcn.111.027284. Epub 2012 Feb 1.

Effect of breastfeeding compared with formula feeding on infant body composition: a systematic review and meta-analysis.

Author information

  • 1Section of Neonatal Medicine, Chelsea & Westminster Hospital Campus, Imperial College London, London, United Kingdom.



Early-life nutrition may influence later body composition. The effect of breastfeeding and formula feeding on infant body composition is uncertain.


We conducted a systematic review and meta-analysis of studies that examined body composition in healthy, term infants in relation to breastfeeding or formula feeding.


PubMed was searched for human studies that reported the outcomes fat-free mass, fat mass, or the percentage of fat mass in breastfed and formula-fed infants. Bibliographies were hand searched, and authors were contacted for additional data. The quality of studies was assessed. Differences in outcomes between feeding groups were compared at prespecified ages by using fixed-effects analyses except when heterogeneity indicated the use of random-effects analyses.


We identified 15 studies for inclusion in the systematic review and 11 studies for inclusion in the meta-analysis. In formula-fed infants, fat-free mass was higher at 3-4 mo [mean difference (95% CI): 0.13 kg (0.03, 0.23 kg)], 8-9 mo [0.29 kg (0.09, 0.49 kg)], and 12 mo [0.30 kg (0.13, 0.48 kg)], and fat mass was lower at 3-4 mo [-0.09 kg (-0.18, -0.01 kg)] and 6 mo [-0.18 kg (-0.34, -0.01 kg)] than in breastfed infants. Conversely, at 12 mo, fat mass was higher in formula-fed infants [0.29 kg (-0.03, 0.61 kg)] than in breastfed infants.


Compared with breastfeeding, formula feeding is associated with altered body composition in infancy.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center