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Nat Rev Immunol. 2012 Feb 3;12(3):168-79. doi: 10.1038/nri3151.

Accessory molecules for Toll-like receptors and their function.

Author information

1
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

Abstract

Toll-like receptors (TLRs) are essential components of the innate immune system. Accessory proteins are required for the biosynthesis and activation of TLRs. Here, we summarize recent findings on TLR accessory proteins that are required for cell-surface and endosomal TLR function, and we classify these proteins based on their function as ligand-recognition and delivery cofactors, chaperones and trafficking proteins. Because of their essential roles in TLR function, targeting of such accessory proteins may benefit strategies aimed at manipulating TLR activation for therapeutic applications.

PMID:
22301850
PMCID:
PMC3677579
DOI:
10.1038/nri3151
[Indexed for MEDLINE]
Free PMC Article

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