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Pediatr Infect Dis J. 2012 Jun;31(6):632-5. doi: 10.1097/INF.0b013e31824acc33.

Therapeutic monitoring of voriconazole in children less than three years of age: a case report and summary of voriconazole concentrations for ten children.

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1
Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.

Abstract

Voriconazole is the treatment of choice for invasive aspergillosis and its use is increasing in pediatrics. Minimal pharmacokinetic data exist in young children. We report voriconazole concentrations for 10 children <3 years of age and pharmacokinetic parameters for 1 infant who had therapeutic drug monitoring performed. Trough concentrations were unpredictable based on dose, highlighting the need to follow values during therapy.

PMID:
22301479
PMCID:
PMC3356483
DOI:
10.1097/INF.0b013e31824acc33
[Indexed for MEDLINE]
Free PMC Article

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