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J Enzyme Inhib Med Chem. 2013 Apr;28(2):289-93. doi: 10.3109/14756366.2011.649269. Epub 2012 Feb 3.

Three new aromatic sulfonamide inhibitors of carbonic anhydrases I, II, IV and XII.

Author information

1
Dipartimento di Chimica, Università di Firenze, Via della Lastruccia, Sesto Fiorentino (Firenze), Italy.

Abstract

4-Sulfamoyl-N-(3-morpholinopropyl)benzamide (I-1), N-(3-morpholinopropyl)benzene-1,4-disulfonamide (I-2) and N-(4-diethylaminoethoxybenzyl)benzene-1,4-bis(sulfonamide (I-3), were prepared and assayed as inhibitors of four carbonic anhydrase (CA) isoenzymes hCA I, hCA II, hCA IV and hCA XII. These compounds exhibited nanomolar half maximal inhibitory concentration (IC(50)) ranging from 58 to 740 nmol/L. All three aromatic sulfonamides show different activities for the isoenzymes studied with lowest affinity against isoenzyme hCA XII.

PMID:
22299577
DOI:
10.3109/14756366.2011.649269
[Indexed for MEDLINE]

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