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Curr Opin Immunol. 2012 Feb;24(1):77-83. doi: 10.1016/j.coi.2012.01.005. Epub 2012 Jan 31.

Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme.

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Charité - Universitätsmedizin Berlin, Institut für Biochemie CVK, Oudenarder Str. 16, 13347 Berlin, Germany.


The immunoproteasome is a specific proteasome isoform induced by interferons. Its proteolytic function has been almost exclusively connected with the adaptive immune response and improved MHC class I antigen presentation. However, IFN-signaling also exposes cells to oxidative stress with concomitant production of nascent-oxidant damaged poly-ubiquitylated proteins. Here we discuss how immunoproteasomes protect cells against accumulation of toxic protein-aggregates and how i-proteasomes dysfunction associates with different diseases. We propose that the immunoproteasome has a central function at the interface between the innate and adaptive immune response and that its predominant protective innate function determines its favorable role in the adaptive immune response.

[Indexed for MEDLINE]

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