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J Am Chem Soc. 2012 Feb 22;134(7):3326-9. doi: 10.1021/ja210304j. Epub 2012 Feb 10.

Model system for cell adhesion mediated by weak carbohydrate-carbohydrate interactions.

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1
Institute of Physical Chemistry, University of Göttingen, Tammannstrasse 6, 37077 Göttingen, Germany.

Abstract

The multivalent carbohydrate-carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed to mimic native cell-cell contacts.The dynamic strength of the homomeric self-association was measured as a function of calcium ions and loading rate. A deterministic model was used to estimate the basic energy landscape and number of participating bonds in the contact zone.

PMID:
22296574
PMCID:
PMC3288207
DOI:
10.1021/ja210304j
[Indexed for MEDLINE]
Free PMC Article

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