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Biomarkers. 2012 Mar;17(2):99-103. doi: 10.3109/1354750X.2011.653986. Epub 2012 Feb 1.

Sequestosome 1/p62: across diseases.

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1
Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.

Abstract

Sequestosome 1/p62 is a signal modulator or adaptor protein involved in receptor-mediated signal transduction. Sequestosome 1/p62 is gaining attention as it is involved in several diseases including Parkinson disease, Alzheimer disease, liver and breast cancer, Paget's disease of bone, obesity and insulin resistance. In this review, we will focus on the most recent advances on the physiological function of p62 relevant to human diseases.

PMID:
22296116
DOI:
10.3109/1354750X.2011.653986
[Indexed for MEDLINE]
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