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Curr Protoc Pharmacol. 2010 Jun;Chapter 5:Unit 5.59. doi: 10.1002/0471141755.ph0559s49.

Novel object recognition in the rat: a facile assay for cognitive function.

Author information

1
Discovery Research, Cephalon, West Chester, Pennsylvania, USA.

Abstract

The rat novel object recognition (NOR) assay is a relatively high-throughput, robust, and sensitive procedure for evaluating compounds for cognition-enhancing activity. For the test, rats are given the opportunity to explore two identical objects for a predetermined period of time. After a delay, the animals are then presented with two objects to explore, one of which is the same as in the first exploration trial, the other a new object. Depending on the length of the delay between the two trials, the rats will either explore the novel object for a greater time period, indicating memory for the familiar object, or will explore the novel and familiar objects for the same amount of time, indicating a lack of recall or loss of memory for the familiar object presented during the initial trial. The protocol described in this unit can be used to evaluate the effects of a compound on the short-term/working memory of adult male rats following a 24-hr inter-trial interval.

PMID:
22294372
DOI:
10.1002/0471141755.ph0559s49
[Indexed for MEDLINE]

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