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Front Physiol. 2012 Jan 25;3:5. doi: 10.3389/fphys.2012.00005. eCollection 2012.

Perspectives of Targeting mTORC1-S6K1 in Cardiovascular Aging.

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1
Laboratory of Vascular Biology, Division of Physiology, Department of Medicine, Faculty of Science, University of Fribourg Fribourg, Switzerland.

Abstract

The global population aging is accelerating and age-associated diseases including cardiovascular diseases become more challenging. The underlying mechanisms of aging and age-associated cardiovascular dysfunction remain elusive. There are substantial evidences demonstrating a pivotal role of the mammalian target of rapamycin complex 1 (mTORC1) and its down-stream effector S6K1 signaling in mammalian lifespan regulation and age-related diseases such as type II diabetes mellitus and cancer. The role of mTORC1-S6K1 in age-related cardiovascular diseases is, however, largely unknown and the available experimental results are controversial. This review article primarily summarizes the most recent advances toward understanding the role of mTORC1-S6K1 in cardiovascular aging and discusses the future perspectives of targeting mTORC1-S6K1 signaling as a healthy lifespan extension modality in anti-aging and anti-cardiovascular aging.

KEYWORDS:

S6K1; aging; eNOS; endothelial senescence; mTOR; oxidative stress; rapamycin; resveratrol

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