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Front Mol Neurosci. 2012 Jan 23;5:2. doi: 10.3389/fnmol.2012.00002. eCollection 2012.

Somatosensory scaffolding structures.

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Departments of Oral and Maxillofacial Surgery, Pharmacology, University of Texas Health Science Center at San Antonio TX, USA.


Dynamic changes in somatosensory perception occur as a result of multiple signaling events. In many instances, over-activation of sensory receptors results in the desensitization and subsequent increased threshold for activation of receptors. In other cases, receptor sensitization can occur following tissue injury and/or inflammation. In both cases, signaling mechanisms that control alterations in receptor activities can significantly affect organism response to sensory stimuli, including thermal, mechanical, and chemical. Due to the homeostatic nature of somatosensory recognition, dynamic changes in receptor response can negatively affect an individual's way of life, as well as alert individuals to tissue damage. Here, we will focus on scaffolding structures that regulate somatosensory neuronal excitability.


AKAP; Jeske; afferent; homer; lipid raft; pain; scaffold

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