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Angew Chem Int Ed Engl. 2012 Mar 12;51(11):2658-61. doi: 10.1002/anie.201108360. Epub 2012 Jan 30.

Photodynamic effect in near-IR light by a photocytotoxic iron(III) cellular imaging agent.

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1
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, Karnataka, India.

Abstract

A red light for cancer cells: an iron(III) complex (1, see picture) that contains an anthracenyl fluorophore moiety and a catecholate ligand is a potent, metal-based PDT agent that efficiently photocleaves DNA in near-infrared light, has significant nuclear uptake, and high photocytotoxicity in red light by an apoptotic pathway in HeLa and MCF-7 cancer cells.

PMID:
22290597
DOI:
10.1002/anie.201108360
[Indexed for MEDLINE]
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