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J Biomed Biotechnol. 2012;2012:520380. doi: 10.1155/2012/520380. Epub 2012 Jan 11.

Flagellar motility of Trypanosoma cruzi epimastigotes.

Author information

1
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del IPN, 07000 México, DF, Mexico.

Erratum in

  • J Biomed Biotechnol. 2012;2012:793487.

Abstract

The hemoflagellate Trypanosoma cruzi is the causative agent of American trypanosomiasis. Despite the importance of motility in the parasite life cycle, little is known about T. cruzi motility, and there is no quantitative description of its flagellar beating. Using video microscopy and quantitative vectorial analysis of epimastigote trajectories, we find a forward parasite motility defined by tip-to-base symmetrical flagellar beats. This motion is occasionally interrupted by base-to-tip highly asymmetric beats, which represent the ciliary beat of trypanosomatid flagella. The switch between flagellar and ciliary beating facilitates the parasite's reorientation, which produces a large variability of movement and trajectories that results in different distance ranges traveled by the cells. An analysis of the distance, speed, and rotational angle indicates that epimastigote movement is not completely random, and the phenomenon is highly dependent on the parasite behavior and is characterized by directed and tumbling parasite motion as well as their combination, resulting in the alternation of rectilinear and intricate motility paths.

PMID:
22287834
PMCID:
PMC3263639
DOI:
10.1155/2012/520380
[Indexed for MEDLINE]
Free PMC Article

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