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Nephrol Dial Transplant. 2012 Jan;27(1):34-41. doi: 10.1093/ndt/gfr736.

Medical management of hepatorenal syndrome.

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1
Department of Medicine, University College London Medical School, London, UK. Andrewdavenport@nhs.net

Abstract

Hepatorenal syndrome (HRS) is defined as the occurrence of renal dysfunction in a patient with end-stage liver cirrhosis in the absence of another identifiable cause of renal failure. The prognosis of HRS remains poor, with a median survival without liver transplantation of <6 months. However, understanding the pathogenesis of HRS has led to the introduction of treatments designed to increase renal perfusion and mean arterial blood pressure using vasopressors and albumin, which has led to improvement in renal function in ∼50% of patients.

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PMID:
22287700
DOI:
10.1093/ndt/gfr736
[Indexed for MEDLINE]
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