Format

Send to

Choose Destination
Virulence. 2012 Jan-Feb;3(1):95-7. doi: 10.4161/viru.3.1.18886. Epub 2012 Jan 1.

Resistance to echinocandins comes at a cost: the impact of FKS1 hotspot mutations on Candida albicans fitness and virulence.

Author information

1
Infectious Diseases Unit, Tel Aviv Medical Center and Sackler School of Medicine, Tel Aviv, Israel. ronenba@tasmc.health.gov.il

Abstract

The emergence of Candida strains carrying FKS1 hotspot mutations associated with resistance to echinocandins is cause for concern. However, to assess the potential of such strains to spread within the community and cause lethal infection, the impact of FKS1 mutations on Candida fitness must be determined. We present evidence that C. albicans fks1 mutations carry significant fitness and virulence costs, which are associated with the production of a thickened, chitin-rich cell wall, impaired filamentation and induction of a dampened inflammatory response. If these phenotypic changes remain stable, they can serve as a basis for rational design of strategies to control the spread of echinocandin resistance.

PMID:
22286697
PMCID:
PMC3337155
DOI:
10.4161/viru.3.1.18886
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center