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Nat Genet. 2012 Jan 29;44(3):269-76. doi: 10.1038/ng.1073.

Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

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1
Institute for Molecular Medicine Finland, University of Helsinki, Finland.

Abstract

Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of serum samples. We identified significant associations (P < 2.31 × 10(-10)) at 31 loci, including 11 for which there have not been previous reports of associations to a metabolic trait or disorder. Analyses of Finnish twin pairs suggested that the metabolic measures reported here show higher heritability than comparable conventional metabolic phenotypes. In accordance with our expectations, SNPs at the 31 loci associated with individual metabolites account for a greater proportion of the genetic component of trait variance (up to 40%) than is typically observed for conventional serum metabolic phenotypes. The identification of such associations may provide substantial insight into cardiometabolic disorders.

PMID:
22286219
PMCID:
PMC3605033
DOI:
10.1038/ng.1073
[Indexed for MEDLINE]
Free PMC Article
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