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Gene. 2012 Apr 1;496(2):69-78. doi: 10.1016/j.gene.2012.01.003. Epub 2012 Jan 18.

Structural biology of the chromodomain: form and function.

Author information

1
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, St. Louis, MO 63104-1079, USA. eissenjc@slu.edu

Abstract

The chromodomain motif is found among certain chromosomal proteins of all eukaryotes. The chromodomain fold - three beta strands packed against a C-terminal alpha helix - mediates protein-protein and/or protein-nucleic acid interactions. In some cases, the affinity of chromodomain binding is regulated by lysine methylation, which appears to target chromodomain proteins and associated complexes to specific sites in chromatin. In this review, our current knowledge of chromodomain structure and function is summarized.

PMID:
22285924
DOI:
10.1016/j.gene.2012.01.003
[Indexed for MEDLINE]

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