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Trends Endocrinol Metab. 2012 Mar;23(3):107-15. doi: 10.1016/j.tem.2011.12.007. Epub 2012 Jan 28.

Insulin signaling - mathematical modeling comes of age.

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Department of Clinical and Experimental Medicine, University of Linköping, SE58185 Linköping, Sweden.


Signaling pathways that only a few years ago appeared simple and understandable, albeit far from complete, have evolved into very complex multi-layered networks of cellular control mechanisms, which in turn are integrated in a similarly complex whole-body level of control mechanisms. This complexity sets limits for classical biochemical reasoning, such that a correct and complete analysis of experimental data while taking the full complexity into account is not possible. In this Opinion we propose that mathematical modeling can be used as a tool in insulin signaling research, and we demonstrate how recent developments in modeling - and the integration of modeling in the experimental process - provide new possibilities to approach and decipher complex biological systems more efficiently.

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