Format

Send to

Choose Destination
Bioinformatics. 2012 Mar 15;28(6):897-9. doi: 10.1093/bioinformatics/bts040. Epub 2012 Jan 27.

SynaptomeDB: an ontology-based knowledgebase for synaptic genes.

Author information

1
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, MD, USA. mpirooz1@jhmi.edu

Abstract

MOTIVATION:

The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.

RESULTS:

We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.

PMID:
22285564
PMCID:
PMC3307115
DOI:
10.1093/bioinformatics/bts040
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center