Next-generation sequencing approaches for genetic mapping of complex diseases

Ferran Casals; Youssef Idaghdour; Julie Hussin; Philip Awadalla

doi:10.1016/j.jneuroim.2011.12.017

Next-generation sequencing approaches for genetic mapping of complex diseases

J Neuroimmunol. 2012 Jul 15;248(1-2):10-22. doi: 10.1016/j.jneuroim.2011.12.017. Epub 2012 Jan 27.

Authors

Ferran Casals¹, Youssef Idaghdour, Julie Hussin, Philip Awadalla

Affiliation

¹ Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada. ferrancasalslopez@gmail.com

PMID: 22285396
DOI: 10.1016/j.jneuroim.2011.12.017

Abstract

The advent of next generation sequencing technologies has opened new possibilities in the analysis of human disease. In this review we present the main next-generation sequencing technologies, with their major contributions and possible applications to the study of the genetic etiology of complex diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chromosome Mapping / methods
Chromosome Mapping / trends*
Genetic Diseases, Inborn / diagnosis
Genetic Diseases, Inborn / genetics*
Genetic Diseases, Inborn / physiopathology
Genetic Predisposition to Disease / genetics*
Genotyping Techniques / methods
Genotyping Techniques / trends
Humans
Sequence Analysis, DNA / methods
Sequence Analysis, DNA / trends