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J Allergy Clin Immunol. 2012 Feb;129(2):335-41. doi: 10.1016/j.jaci.2011.12.968.

Advances in mechanisms of asthma, allergy, and immunology in 2011.

Author information

1
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Mass 02115, USA. jboyce@rics.bwh.harvard.edu

Abstract

2011 was marked by rapid progress in the identification of basic mechanisms of allergic disease and the translation of these mechanisms into human cell systems. Studies published in the Journal of Allergy and Clinical Immunology this year provided new insights into the molecular determinants of allergenicity, as well as the environmental, cellular, and genetic factors involved in sensitization to allergens. Several articles focused on mechanisms of allergen immunotherapy and the development of novel strategies to achieve tolerance to allergens. Additional studies identified substantial contributions from T(H)17-type cells and cytokines to human disease pathogenesis. Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review.

PMID:
22284930
DOI:
10.1016/j.jaci.2011.12.968
[Indexed for MEDLINE]

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