Format

Send to

Choose Destination
Trends Endocrinol Metab. 2012 Mar;23(3):116-24. doi: 10.1016/j.tem.2011.12.005. Epub 2012 Jan 26.

Insulin-sensitive obesity in humans - a 'favorable fat' phenotype?

Author information

1
Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney 2010, Australia. d.samochabonet@garvan.org.au

Abstract

In most humans, obesity and insulin resistance coexist. However, a unique group of obese individuals, who exhibit better insulin sensitivity than expected for their adiposity, has been the focus of recent research interest. We critically examine cross-sectional and lifestyle intervention studies in obese humans classified as 'insulin-sensitive' versus 'insulin-resistant' and review the few longitudinal studies comparing rates of cardiovascular disease, type 2 diabetes and all-cause mortality in these groups of individuals. We suggest that reduced deposition of fat, particularly of bioactive lipid intermediates, in muscle and liver is potentially protective. We propose that dynamic interventional studies in insulin-sensitive obese humans may increase understanding of the metabolic factors that play a role in obesity-associated insulin resistance in humans.

PMID:
22284531
DOI:
10.1016/j.tem.2011.12.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center