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J Clin Anesth. 2012 Feb;24(1):3-7. doi: 10.1016/j.jclinane.2011.09.001.

Meta-analysis of the effect of central neuraxial regional anesthesia compared with general anesthesia on postoperative natural killer T lymphocyte function.

Author information

1
Department of Anaesthesia, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland. iancm25@hotmail.com

Abstract

STUDY OBJECTIVE:

To compare the effect of central neuraxial (spinal or epidural) anesthesia with general anesthesia on postoperative natural killer (NK) T lymphocyte function.

DESIGN:

Meta-analysis.

SETTING:

University-affiliated hospital.

MEASUREMENTS:

A systematic search of the medical literature from 1966 to 2009 yielded 5 eligible studies with a total of 184 patients who received neuraxial blockade. Natural killer T lymphocyte function was studied.

MAIN RESULTS:

There was significant heterogeneity between the studies [I(2) = 94.4% (95% CI= 90.3-96.2%)]. Overall fixed-effect odds ratio was 0.86 (0.66-1.14, P = 0.25). The random-effect odds ratio was 1.13 (0.26-4.92, P = 0.79).

CONCLUSION:

Anesthetic technique does not appear to significantly affect postoperative NK T lymphocyte function. Given the heterogeneity observed, further clinical studies in cancer patients of the effect of anesthetic technique on immune function in general, and NK T lymphocyte function in particular, are needed.

Comment in

PMID:
22284311
DOI:
10.1016/j.jclinane.2011.09.001
[Indexed for MEDLINE]

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