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J Am Chem Soc. 2012 Feb 15;134(6):2888-91. doi: 10.1021/ja2107492. Epub 2012 Feb 2.

Rolling circle amplification-templated DNA nanotubes show increased stability and cell penetration ability.

Author information

1
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC H3A 2K6 Canada.

Erratum in

  • J Am Chem Soc. 2012 Mar 21;134(11):5426.

Abstract

DNA nanotubes hold promise as scaffolds for protein organization, as templates of nanowires and photonic systems, and as drug delivery vehicles. We present a new DNA-economic strategy for the construction of DNA nanotubes with a backbone produced by rolling circle amplification (RCA), which results in increased stability and templated length. These nanotubes are more resistant to nuclease degradation, capable of entering human cervical cancer (HeLa) cells with significantly increased uptake over double-stranded DNA, and are amenable to encapsulation and release behavior. As such, they represent a potentially unique platform for the development of cell probes, drug delivery, and imaging tools.

PMID:
22283197
DOI:
10.1021/ja2107492
[Indexed for MEDLINE]

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