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IARC Sci Publ. 1990;(104):113-20.

Approaches used by the US National Toxicology Program in assessing the toxicity of chemical mixtures.

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Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.


The US National Toxicology Program has made a definite commitment towards improving the understanding and predictability of the toxicity of chemical mixtures. The commitment has consisted of a thorough review by the National Research Council of the state of the art of complex mixture testing and strategy for in vivo tests as well as a series of laboratory studies to better characterize the toxicity of selected chemical mixtures and research programmes to improve our ability to predict the toxicological properties of other mixtures.

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