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Wei Sheng Yan Jiu. 2011 Nov;40(6):727-31.

[Equol-producing phenotype and in relation to serum sex hormones among healthy adults in Beijing].

[Article in Chinese]

Author information

1
Department of Social Medicine & Health Education, School of Public Health, Peking University, Beijing 100191, China. eddy-liu331@163.com

Abstract

OBJECTIVE:

To evaluate relations between equol-producing phenotype and serum sex hormones among adults in Beijing.

METHODS:

90 male and 90 female adults participated in a cross-sectional study and provided twice 24h urine samples on a regular diet and after 3-d soy isoflavone challenge respectively. A health and demographics questionnaire, and 2 days food record were completed before the urine collection. Isoflavones and their metabolites in urine were measured to determine equol phenotype by HPLC.

RESULTS:

The serum total testosterone level of the male and the serum estradiol and progesterone levels among the female participants were no significant differences between the equol producers and non-producers (P > 0.05). There were negative correlations between urinary total isoflavone, daidzein, equol, O-desmethylangolensinl, glysitein, dihydroglysitein levels and serum total testosterone concentration among the male equol producers on a regular diet (r = -0.29 - -0.36, P < 0.05). There were no significant correlations between urinary isoflavonoid excretion and serum estradiol and progesterone concentration among the female participants on a regular diet (P > 0.05), regardless of equol phenotype.

CONCLUSION:

The result suggests that exposure of isoflavone is correlated with the testosterone in healthy men under the usually lifestyle, and may be related to equol phenotype.

PMID:
22279666
[Indexed for MEDLINE]

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