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J Infect Dis. 2012 Mar 15;205(6):1019-23. doi: 10.1093/infdis/jir874. Epub 2012 Jan 25.

Infection with Cryptosporidium hominis provides incomplete protection of the host against Cryptosporidium parvum.

Author information

1
Department of Biomedical Sciences, Tufts University, North Grafton, MA, USA. abhineet.sheoran@tufts.edu

Abstract

Cryptosporidium hominis and Cryptosporidium parvum, which infect humans equally, are genetically/antigenically almost identical. It remains unclear, however, whether infection with C. hominis protects against C. parvum. Gnotobiotic piglets were used to investigate cross-protection. After ≥3 days of recovery from C. hominis infection, the piglets were completely protected against subsequent challenge with C. hominis but only partially against challenge with C. parvum, as compared with age-matched control animals challenged with either species. In conclusion, C. hominis-specific immunity was sufficient to completely protect against challenge with the same species but insufficient to provide the same level of protection against C. parvum.

PMID:
22279124
PMCID:
PMC3415952
DOI:
10.1093/infdis/jir874
[Indexed for MEDLINE]
Free PMC Article
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