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IUBMB Life. 2012 Mar;64(3):231-41. doi: 10.1002/iub.608. Epub 2012 Jan 25.

The role of PGC-1 coactivators in aging skeletal muscle and heart.

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Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, FL, USA.


Aging is the progressive decline in cellular, tissue, and organ function. This complex process often manifests as loss of muscular strength, cardiovascular function, and cognitive ability. Mitochondrial dysfunction and decreased mitochondrial biogenesis are believed to participate in metabolic abnormalities and loss of organ function, which will eventually contribute to aging and decreased lifespan. In this review, we discuss what is currently known about mitochondrial dysfunction in the aging skeletal muscle and heart. We focused our discussion on the role of PGC-1 coactivators in the regulation of mitochondrial biogenesis and function and possible therapeutic benefits of increased mitochondrial biogenesis in compensating for mitochondrial dysfunction and circumventing aging and aging-related diseases.

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