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Inflamm Res. 2012 Mar;61(3):177-88. doi: 10.1007/s00011-011-0427-1. Epub 2012 Jan 26.

TLR4 polymorphisms and disease susceptibility.

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1
NUST Centre of Virology and Immunology, National University of Sciences and Technology, H-12, Islamabad, Pakistan. mamoona786@hotmail.com

Abstract

Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal to mycobacterial pathogens and some endogenous ligands. A complex signaling cascade initiates after the ligand binds to the TLR4 ectodomain, leading to the activation of multiple inflammatory genes. Genetic variations greatly influence immune responses towards pathogenic challenges and disease outcome. In this review, we summarize various reports regarding TLR4 polymorphisms and disease susceptibility.

PMID:
22277994
DOI:
10.1007/s00011-011-0427-1
[Indexed for MEDLINE]
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