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BMJ. 2011 Jan 25;344:d7901. doi: 10.1136/bmj.d7901.

Effectiveness of vaccine against pandemic influenza A/H1N1 among people with underlying chronic diseases: cohort study, Denmark, 2009-10.

Author information

1
Division of Epidemiology, Statens Serum Institut, Copenhagen, Denmark. hde@ssi.dk

Abstract

OBJECTIVE:

To determine the effectiveness of an adjuvanted monovalent vaccine against pandemic influenza A/H1N1 among people with underlying chronic diseases.

DESIGN:

Historical cohort study.

SETTING:

Mandatory national reporting systems, 2 November 2009 to 31 January 2010, Denmark.

PARTICIPANTS:

388,069 people under 65 years of age with a diagnosis in the past five years of at least one underlying disease expected to increase the risk of severe illness after influenza.

MAIN OUTCOME MEASURES:

Laboratory confirmed H1N1 infection and influenza related hospital admission with laboratory confirmed H1N1 infection. Estimates of vaccine effectiveness were adjusted for age and underlying disease.

RESULTS:

The effectiveness of pandemic vaccine against confirmed H1N1 infection 14 days after one dose of vaccine was 49% (95% confidence interval 10% to 71%). The effectiveness of vaccine against admission to hospital for confirmed H1N1 infection was 44% (-19% to 73%).

CONCLUSIONS:

The adjuvanted monovalent vaccine against pandemic influenza A/H1N1 was offered late in the 2009-10 influenza season. Among chronically ill people, this vaccine offered protection against laboratory confirmed H1N1 infection but only offered non-significant protection against influenza related hospital admissions confirmed as H1N1 infection. This finding is of public health relevance because the population of chronically ill people is a major target group for pandemic vaccinations and because of the delayed availability of pandemic vaccines in a forthcoming pandemic.

PMID:
22277542
DOI:
10.1136/bmj.d7901
[Indexed for MEDLINE]

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