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J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):196-201. doi: 10.1177/1470320311434240. Epub 2012 Jan 25.

Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis.

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1
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seongbuk-gu, Seoul, Korea. lyhcgh@korea.ac.kr

Abstract

INTRODUCTION:

To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme (ACE) confers susceptibility to vasculitis.

MATERIALS AND METHODS:

A meta-analysis was conducted on the associations between the ACE I/D polymorphism and vasculitis.

RESULTS:

Twelve studies, including four on Behçet's disease (BD), four on Henoch-Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener's granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214-1.468, p = 7.4 × 10(-5)). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017-1.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021-2.049, p = 0.038; OR 1.881, 95% CI 1.385-2.595, p = 6.6 × 10(-5)). On the other hand, meta-analysis showed no association between KD and the ACE I/D polymorphism.

CONCLUSIONS:

This meta-analysis shows that the ACE I/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP.

PMID:
22277255
DOI:
10.1177/1470320311434240
[Indexed for MEDLINE]
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