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Ecancermedicalscience. 2010;4:175. doi: 10.3332/ecancer.2010.175. Epub 2010 Mar 18.

Metachronous bladder metastases from renal cell carcinoma: a case report and review of the literature.

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Department of Urology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy.



adrenal gland, parotid gland, pharynx, eye and bladder are rare localizations of metastases of renal cell carcinoma (RCC). We report a case of metachronous RCC metastases to the bladder in a patient with a medical history of transitional cell carcinoma (TCC) of the bladder.


a case study and review of the relevant literature are presented.


during a follow-up cystoscopy examination following treatment of TCC, a single 5-mm lesion was detected and endoscopically resected. The histology of the resected sample was confirmed to be RCC, comparable to a primary kidney cancer and not recurrent TCC.


the patient had a probability of metastases three years after nephrectomy of 62.9%. Survival rates following single metastasectomy are 60% and 38% at three and five years, respectively; metachronous diagnosis has a better prognosis than synchronous. During RCC follow-up, each lesion should be considered as a possible metastasis of RCC.

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