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Int J Mol Sci. 2011;12(12):8947-60. doi: 10.3390/ijms12128947. Epub 2011 Dec 6.

The role of the E2F transcription factor family in UV-induced apoptosis.

Author information

1
Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia. m.rethinam@uq.edu.au

Abstract

The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.

KEYWORDS:

E2F; UV; apoptosis; sunburn cells

PMID:
22272113
PMCID:
PMC3257110
DOI:
10.3390/ijms12128947
[Indexed for MEDLINE]
Free PMC Article

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