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Inflamm Bowel Dis. 2012 Nov;18(11):2063-71. doi: 10.1002/ibd.22889. Epub 2012 Jan 23.

Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease.

Collaborators (701)

Gendre JP, Godeberge P, Hugot JP, Lémann M, Nahon S, Sabaté JM, Tucat G, Colombel JF, Cosnes J, Gendre J, Lémann M, Hébuterne X, Cortot A, Bouhnik Y, Laharie D, Dupas JL, Flourié B, Lerebours E, Beaugerie L, Peyrin-Biroulet L, Allez M, Messing B, Cadiot G, Marteau P, Soulé J, Gornet JM, Veyrac M, Duclos B, Beau P, Bourreille A, Baumer P, Carbonnel F, Heresbach D, Metman EH, Florent C, Blain A, Faucheron JL, Potier P, Boehm C, Kurtz T, Lamouliatte H, Nion-Larmurier I, Delchier JC, Chaussade S, Weiss AM, Cézard JP, Siproudhis L, Nahon S, Sondag D, Jian R, Souquet JC, Bord P, Coffin B, D'almagne H, Delasalle P, Fournier R, Cavicchi M, Souffran MH, Vandromme L, Guedon C, Seksik P, Michiels C, Renard P, Rogier P, Gouilloud S, Rotenberg A, Savoye G, Thevenin A, Mallet L, Brazier F, Jean F, Justum AM, Latrive JP, Gerbal JL, Pierrugues R, Chardonnal G, Picon L, Reix N, D'aubigny ND, Uettwiller H, Mallet AC, Palacci A, Bensaude RJ, Bonniaud P, Empinet O, Nisard A, Rudelli A, Tubiana B, Capelle P, Dabadie A, Evard D, Julien PE, Picon-Coste M, Schneider S, Goldfain D, Bellanger J, Blondelot JP, Lamy P, Lemière S, Mockly JF, Pellat B, Gatineau-Sailliant G, Nalet B, Nancey S, Kusielewicz D, Loison P, Popot JM, Merite F, Roux JP, Afchain P, Blanquart A, Heyries L, Reville M, Viron D, Zerbib F, Claviere C, Léostic D, Pouderoux P, Moitry A, Hagège H, Hugot JP, Humeau B, Sabate JM, Lederman E, Lescut D, Luneau F, Mesnard B, Smadja L, Steinberg M, Brun M, Macaigne G, Marchal JL, Ollivier S, Ouvry D, Perche JP, Rambaud S, Benamouzig R, Cazenave JL, Coffin JC, Blazquez M, Lagneau M, Person B, Wittersheim C, Napoleon B, Cemachovic I, Iglicki F, Howaizi M, Leprince E, Leurent B, Morin T, Darsouni R, Attar A, Baron P, Breton A, Gillion JM, Guemene JM, Jouffre C, Moreau X, Claude P, Quinton A, Abitbol V, Brichard JM, Desaint B, Bouygues M, Chatrenet P, Salmeron M, Silvie J, Waldner B, Emery Y, Moraillon A, Kunkel D, Dubois P, Faure P, L'Hirondel C, Labérenne JE, Moreau P, Pereira A, Plihon G, Wolff T, Ngo Y, Boruchowicz A, Jost B, Gotlib JP, Danne O, Raoux P, Ramond-Bouhali MJ, Baetz A, Veyres B, Chapoutot C, Le Dréau G, Filippi J, Mudry J, Kalt P, Minault S, Bounin PA, Andréani T, Charneau J, Reijasse D, Bolze JL, Thaunat JL, Le Couteulx C, Maurage C, Bader R, Codjovi P, Migairou JL, Morali A, Rey P, Molard BR, Petit R, Koch S, Cassan P, Deschamps JP, Caby CM, Meurisse JJ, Prades P, Boulant J, Diacono M, Monsch JM, Dupuy JF, Bellaiche G, Guegan M, Comte JM, Cayla JM, Tallec FL, Meurisse F, Desurmont P, Roget L, Bouyssou P, Le Gall B, Bloch F, Larvol L, Jullien M, Moreau J, Rebouissoux L, Decroix B, Dib N, Dieterling P, Lenormand F, Lagier E, Fallourd P, Charpin S, Bertrand H, Bommelaer G, Battistelli D, Delon B, Dentant L, Dorval E, Dumortier J, Gaye- Bareyt E, Gerosa Y, Guez C, Mornet M, Benfredj P, Piperaud R, Stremsdoerfer N, Verdier E, Grinholtz A, Barjonet G, See A, Arotçarena R, Baudet A, Broyer J, Charachon A, Blondon H, Mouton P, Claudez H, Labat-Labourdette J, Haëm J, Estable P, Levy P, Rosenbaum A, Balavoine Y, Blanchi A, Coutarel P, Delaperriere N, Dervichian M, Marois F, Seroka J, Michaud L, Leroy O, Meyran E, Poilroux B, Tensaouti A, Paupard T, Agard D, Beaulieu S, Benfiguig K, Capony P, Cottereau J, Desreumaux P, Dramard JM, Duché M, Mamou P, Etienney I, D'Abrigeon G, Godeberge B, Tucat G, Puech J, Roger J, Lapalus MG, Bauret P, Houcke P, Pornin B, Champigneulle B, Cuissard L, David XR, Lombard F, Granveau A, Hamon JF, Ink O, Blondel F, Namias A, Pillon D, Reignier A, Tordjman G, Christidis C, Zirabe S, Audebert M, Bion E, Bourgeaux C, Poupardin C, Deplaix P, Fratini G, Garnier T, Desseaux G, Magois H, Lochum S, Vergier JF, Texereau P, Rat C, Uzzan F, Vidal A, Vinante N, Watrin B, Wurtz-Huckert C, Barre B, Ferbus DC, Contou JF, Coupier D, David B, Gargot D, Huc D, Barraya R, Faroux R, Fourgeaud JL, Grimprel H, Auroux J, Rey JF, Arnoux JP, Lentini F, Tardy L, Mouterde O, Spyckerelle C, Vacherot B, Weissman A, Alpérine M, Sidaner AL, Bonnet-Eymard PO, Colson JL, Pellet D, Deltombe B, Edouard A, Maechel H, Jaillet JC, Genes J, Leveque AM, Lucidarme D, Maignan P, Gehrke NM, Sanchez J, Tusseau F, Casteur A, Bottlaender J, Constantini D, Coton T, Even P, Druart F, Riot F, Gauchet JM, Hecquet G, Henry G, Hochain P, Arpurt JP, Medini A, Dartois-Hoguin M, Moindrot H, Emery P, Periac P, Prunier A, Renkes P, Tawil-Longreen C, Vincent E, Vitte RL, Loeb C, Carwana A, Barbereau D, Bohon P, Corrieri-Baizeau C, Sahy D, Derreveaux P, David D, Desbazeille F, Fontenelle P, Slama JL, Le Mercier Y, Certin M, Reig JJ, Rosa I, Helbert T, Tounian P, Turner L, Perot V, Aillet L, Pauwels A, Barré P, Nury B, Cazalbou C, Devulder F, Durget A, Dubroca J, Gaudy D, Greff M, Jacques C, Lafarge J, Kezachian G, Le Gall R, Pariente A, Pinault T, Bismuth M, Boyer-Darrigrand N, Bretagnolle P, Carpentier S, Cholet F, Theodore C, Combes R, Combet F, Delanoe C, De Montigny S, Soudan D, Fourdan O, Minier G, Languepin J, Roche J, Ginies JL, Nouel O, Petitgars P, Robin E, Hamm R, Roques JF, Roussin-Bretagne S, Sénéjoux A, Muron S, Bardoux N, Berthelemy P, Madonia P, Carles B, Reynier C, Cuillerier E, Dadamessi I, Danis J, Debenes B, Dubuc-Rey N, Lesur G, Jouet P, Lenaerts C, Garret M, Mineur A, Chabry B, Pigot F, Rossi V, Tennenbaum R, Salloum J, Slaoui MH, Mathieu S, Papapietro V, Viola S, Bezet A, Altman C, Audan A, Calabet J, Masliah C, Fayemendy L, Duruy M, Gauffeny B, Helie L, Imani K, Janin-Manificat R, Galmiche JP, Kerlirzin A, Bedenne L, Locher C, Michaudel G, Missonnier G, Rinaldi-Dovio M, Rouillon JM, Ecuer S, Patenotte A, Bronstein JA, Baty V, Bougnol M, Bourbon P, Cerbelaud P, Chavaillon A, Boiffin F, Dubern B, De Laguierce ID, Greco F, Bouhot F, Godeberge P, Grandmaison B, Gros P, Targues G, Corallo J, Boutin J, Guillan J, Barbieux JP, Lariviere IL, Genissel HL, Leroi H, Bellaiche M, Elie-Legrand MC, Dapoigny M, Denoyel P, Pienkowski P, Pouche P, Saurfelt MM, Thorel JM, Piche T, Travers B, Tuvignon P, Zalcberg M, Boulay G, Zamora C, Samama J, Ricotie E, De Fleury P, Maille F, Mougenel JL, Gonot O, Menat JP, Kaassis M, Lang F, Abramowitz L, Ganne N, Pecriaux O, Seyrig JA, Sobhani I, Parmentier T, Van Nieuwenhuyse A, Weber FX, Glibert A, Bineau C, Canet B, Collin C, Cordet F, Parlier DD, Carre D, Peytier A, Fein F, Barouk J, Dewannieux J, Hartwig J, Jouve JL, Laplane B, Lascar G, Legrand C, Marchand PL, Liebaert MP, Terdiman-Pire M, Abdelli N, Neveu D, De La Lande P, De Saint Louvent P, Pelatan C, Petit A, Richecoeur M, Texier F, Cazals JB, Tissot B, Mourrut C, Doubremelle M, Foltz M, Gautier- Jubé F, Martin J, Khouri E, Lons T, Carlier-Bandu M, Monnin JL, Roche H, Willemin B, Houard X, Fatisse A, Algard M, Arab K, Borel I, Lagarrigue C, Chryssostalis A, Boutroux D, Dupuychaffray JP, Khaddari S, Mion F, Puy-Montbrun T, Girardet JP, Gury B, Landau A, Bihan ML, Nieuviarts S, Ollivry J, Bourgeois PL, Piquet MA, Escartin M-, Systchenko R, Venezia F, Wantiez M, Lesage X, Zrihen E, Aygalenq P, Dieumegard B, Savarieau B, Bulois P, Cattan S, Diez JL, Fauchot O, Durous E, Gazut V, Guilleminet C, Bories JM, Floch IJ, Vove JP, Lelouch S, Lévy P, Lhopital F, Marcato N, Mozer-Bernardeau M, Nousbaum JB, Cattan P, Plane A, Raymond JM, Roseau G, Rozental G, Boustiè re C, Bonny C, Cordier-Collet M, Courat L, Croguennec B, Delaunay- Tardy K, Labarriere D, Geagea E, Gottrand F, Gelsi E, Thiefin G, Wohlschies E, Miguet M, Ponsot P, Suzanne J, Teste Y, Dupont Gossart A, Baroni JL, Benchaa B, Blanc G, Maroy B, Bonjean P, Brézault C, Bridoux-Henno L, Chayette C, Auby D, Fiorucci R, Galindo G, Hubert G, Bonneau G, Marinier E, Pouteau M, Alamdari A, Delbende B, Chamouard P, D'Abravanel P, Dall'Osto H, Hervé S, Lefebvre J, Levoir D, Lillo P, Rouch M, Mathonnet M, De Lustrac M, Ramond FJ, Roupret B, Soupison A, Ait-Ouadda D, Barbaza Y, Bayart B, Bottini T, Cochet F, Goderel I, Maury O, Mbonyingo L, Pourtau V, Romain-Huttin L, Sallé AV, Trang J, Admane H, Drouet E.

Abstract

BACKGROUND:

It remains to be shown whether inflammatory bowel disease (IBD) is associated with an increased risk of primary intestinal lymphoproliferative disorders (PILD). We assessed this risk in the CESAME French nationwide prospective observational cohort.

METHODS:

In all, 680 gastroenterologists enrolled 19,486 patients with IBD (Crohn's disease in 60.3%) from May 2004 to June 2005. Follow-up ended on 31 December 2007. Available biopsy samples and surgical specimens from patients with PILD (n = 14) were centralized for review. The reference incidence of PILD in the general population was obtained from the Côte d'Or registry and was used as a comparator to assess the standardized incidence ratio (SIR). The influence of thiopurine exposure was explored in a nested case-control study.

RESULTS:

In the CESAME population the crude incidence of PILD was 0.12/1000 patient-years, with a corresponding SIR of 17.51 (95% confidence interval [CI], 6.43-38.11; P < 0.0001). The risk was highest in patients exposed to thiopurines (SIR 49.52, 95% CI 13.49-126.8; P < 0.0001), while it did not reach statistical significance in patients naïve to thiopurines (SIR 4.83, 95% CI, 0.12-26.91; P = 0.37). The odds ratio associated with ongoing thiopurine exposure (vs. naïve) was 2.97 (95% CI, 0.30-infinity; P = 0.38). All 14 cases of PILD were non-Hodgkin's B-cell LD, 78.6% occurred in males, 85.7% arose in IBD lesions, and 45.5% were Epstein-Barr virus-positive. Eleven cases occurred in patients with Crohn's disease. Mean (SD) age at PILD diagnosis was 55.1 (5.6) years and the median time since IBD onset was 8.0 years (interquartile range, 3.0-15.8).

CONCLUSIONS:

Patients with IBD have an increased risk of developing PILD.

PMID:
22271569
DOI:
10.1002/ibd.22889
[Indexed for MEDLINE]
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