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J Cell Biol. 2012 Jan 23;196(2):189-201. doi: 10.1083/jcb.201103008.

The Ras protein superfamily: evolutionary tree and role of conserved amino acids.

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1
Computational Cell Biology Group, Institute for Predictive and Personalized Medicine of Cancer, 08916 Badalona, Barcelona, Spain. arojas@imppc.org

Erratum in

  • J Cell Biol. 2012 Feb 20;196(4):545.

Abstract

The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex relationships between the evolution of this protein superfamily sequence and the acquisition of distinct cellular functions. Together with advances in computational methods and structural studies, the sequence information has helped to identify features important for the recognition of molecular partners and the functional specialization of different members of the Ras superfamily.

PMID:
22270915
PMCID:
PMC3265948
DOI:
10.1083/jcb.201103008
[Indexed for MEDLINE]
Free PMC Article
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