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Nat Med. 2012 Jan 22;18(2):224-6. doi: 10.1038/nm.2608.

Prostaglandin E2 promotes intestinal tumor growth via DNA methylation.

Author information

1
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Abstract

Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression.

PMID:
22270723
PMCID:
PMC3274627
DOI:
10.1038/nm.2608
[Indexed for MEDLINE]
Free PMC Article

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