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Obstet Gynecol. 2012 Feb;119(2 Pt 2):438-42. doi: 10.1097/AOG.0b013e318240090e.

Favorable response to antigonadal therapy for a benign metastasizing leiomyoma.

Author information

1
Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1590, USA. dasilvaa@nhlbi.nih.gov

Abstract

BACKGROUND:

Benign metastasizing leiomyoma and lymphangioleiomyomatosis (LAM) both are characterized by abnormal proliferation of smooth muscle-like cells in the lung.

CASE:

A 32-year-old African woman with a diagnosis of LAM underwent myomectomy for uterine leiomyomas. An alternative diagnosis of benign metastasizing leiomyoma was made on repeat lung biopsy. Treatment with leuprolide acetate decreased pulmonary infiltrates and improved lung function and exercise tolerance.

CONCLUSION:

Accurately diagnosing benign metastasizing leiomyoma has important implications for clinical outcome. Because its clinical presentation may be misleading, immunohistochemical techniques may assist in differentiating benign metastasizing leiomyoma from LAM. This is important because, in benign metastasizing leiomyoma, reduced tumor burden and improved pulmonary function may be achieved by suppressing gonadal steroids.

PMID:
22270431
PMCID:
PMC3266540
DOI:
10.1097/AOG.0b013e318240090e
[Indexed for MEDLINE]
Free PMC Article

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