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Genome Biol. 2012 Jan 23;13(1):238. doi: 10.1186/gb-2012-13-1-238.

Transcriptional enhancers in development and disease.

Author information

1
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. nsakabe@uchicago.edu

Abstract

Distal transcription enhancers are cis-regulatory elements that promote gene expression, enabling spatiotemporal control of genetic programs such as those required in metazoan developmental processes. Because of their importance, their disruption can lead to disease.

PMID:
22269347
PMCID:
PMC3334578
DOI:
10.1186/gb-2012-13-1-238
[Indexed for MEDLINE]
Free PMC Article

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