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Mol Brain. 2012 Jan 23;5(1):2. doi: 10.1186/1756-6606-5-2.

Understanding the physiological roles of the neuronal calcium sensor proteins.

Author information

1
Department of Cellular and Molecular Physiology, The Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. burgoyne@liv.ac.uk

Abstract

Calcium signalling plays a crucial role in the control of neuronal function and plasticity. Changes in neuronal Ca2+ concentration are detected by Ca2+-binding proteins that can interact with and regulate target proteins to modify their function. Members of the neuronal calcium sensor (NCS) protein family have multiple non-redundant roles in the nervous system. Here we review recent advances in the understanding of the physiological roles of the NCS proteins and the molecular basis for their specificity.

PMID:
22269068
PMCID:
PMC3271974
DOI:
10.1186/1756-6606-5-2
[Indexed for MEDLINE]
Free PMC Article

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