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Clin Microbiol Infect. 2013 Jan;19(1):85-90. doi: 10.1111/j.1469-0691.2011.03750.x. Epub 2012 Jan 23.

Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model.

Author information

1
INSERM, U895, Centre Méditerranéen de Médecine Moléculaire, C3M, Microbial Toxins and Host Interactions; University Nice-Sophia-Antipolis, IFR50, UFR Médecine; Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Nice, Hôpital Archet II, CHU Nice. Electronic address: xavier.nassif@inserm.fr.
2
INSERM, UMR-S 722; University Paris Nord, Sorbonne Paris Cité, UFR Santé, Médecine, Biologie Humaine; Laboratoire de Bactériologie, Assistance Publique Hôpitaux de Paris, AP-HP, Hôpital Avicenne, Bobigny.
3
INSERM, U1002.
4
Institut Pasteur, Genotyping of Pathogens and Public Health, Paris.
5
Laboratoire de Bacteriologie, CHU de Brest, University Bretagne Occidentale, Brest.
6
Faculté de Médecine, Hôpital Européen Georges Pompidou, AP-HP, and Paris Descartes.
7
INSERM, UMR-S 722; Sorbonne Paris Cité, Faculté de Médecine, University Paris Diderot, Site Xavier Bichat.
8
INSERM, U895, Centre Méditerranéen de Médecine Moléculaire, C3M, Microbial Toxins and Host Interactions; University Nice-Sophia-Antipolis, IFR50, UFR Médecine.
9
INSERM, U1002; Faculté de Médecine, University Paris Descartes; Laboratoire de Bactériologie, AP-HP, Hôpital Necker-Enfants Malades, Paris, France.

Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) strains, a major cause of bacteraemia, typically belong to phylogenetic group B2 and express diverse accessory traits that contribute to virulence in mouse infection models. However, their high genomic diversity obscures the relationship between virulence factors and severity of infection in patients. In this study, we analysed concomitantly the strain's expression of virulence in a mouse model, genomic determinants and the clinical severity of infection in 60 bacteraemic patients. We show that bacterial virulence based on an animal model study and virulence factor determination is not correlated with pejorative outcome of E. coli human blood infections.

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